International Journal of Research and Development in Engineering Sciences https://www.ijrdes.com K. Kantha Raju 2 2 (March - April) 2020 04 March-April enDisease PredictionData MiningMachine LearningClassification AlgorithmsHealthcare AnalyticsPredictive Modeling With the exponential growth of healthcare data disease prediction has become a crucial area of research in medical data analytics This paper presents an approach that combines data mining techniques and machine learning algorithms to predict diseases accurately and efficiently The proposed system analyzes patient data such as medical history symptoms lifestyle patterns and clinical test results to identify potential health risks Data preprocessing and feature selection are performed to eliminate noise and improve prediction accuracy Machine learning models such as Decision Trees Random Forest Nave Bayes and Support Vector Machines SVM are applied to classify and predict diseases based on extracted features Comparative analysis demonstrates that hybrid and ensemble models outperform traditional statistical methods in terms of precision and recall The integration of data mining with machine learning enables the discovery of hidden patterns and correlations within healthcare datasets supporting early diagnosis and preventive healthcare strategies This research contributes to the development of intelligent datadriven medical decisionsupport systems Copyright (c) 2026 International Journal of Research and Development in Engineering Sciences. All rights reserved. 2020 All Rights Reserved